Article
Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk.
The American journal of gastroenterology - 1 Feb 2010
Festen Eleonora A M, Stokkers Pieter C F, van Diemen Cleo C, van Bodegraven Adriaan A, Boezen H Marieke, Crusius Bart J A, Hommes Daniel W, van der Woude C Janneke, van der Woude Janneke C, Balschun Tobias, Verspaget Hein W, Schreiber Stephan, de Jong Dirk J, Franke Andre, Dijkstra Gerard, Wijmenga Cisca, Weersma Rinse K
Abstract excerpt
OBJECTIVES: Genetic susceptibility is known to make a major contribution to the pathogenesis of ulcerative colitis (UC). Recently, three studies, including a genome-wide association study (GWAS), reported novel UC risk loci. METHODS: The top-20 single-nucleotide polymorphisms (SNPs) from the first UC-GWAS were genotyped, as part of the study's replication phase, in 561 UC cases and 728 controls from our Dutch UC...
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