Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac disease.

doi:10.1038/ajg.2009.163

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac disease.

The American journal of gastroenterology - 1 Jul 2009

Glas Jürgen, Stallhofer Johannes, Ripke Stephan, Wetzke Martin, Pfennig Simone, Klein Wolfram, Epplen Jörg T, Griga Thomas, Schiemann Uwe, Lacher Martin, Koletzko Sibylle, Folwaczny Matthias, Lohse Peter, Göke Burkhard, Ochsenkühn Thomas, Müller-Myhsok Bertram, Brand Stephan

Abstract excerpt

OBJECTIVES: Recently, a genome-wide association study showed that single-nucleotide polymorphisms (SNPs) in the chromosome 4q27 region containing IL2 and IL21 are associated with celiac disease. Given the increased prevalence of inflammatory bowel disease (IBD) among celiac disease patients, we investigated the possible involvement of these SNPs in IBD. METHODS: Five SNPs strongly associated with celiac disease...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Distribution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Celiac Disease

Share to Colitis, Ulcerative

Share to Confidence Intervals

Share to Interleukin-2

Share to Interleukin-21

Share to Receptors, Interleukin

Share to Sex Distribution

Source

Open in PubMed

Identifiers

PMID: 19455118
DOI: 10.1038/ajg.2009.163

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac disease.PMID 19455118Read ↗

Haplotype-based analysis of ulcerative colitis risk loci identifies both IL2 and IL21 as susceptibility genes in Han Chinese.Semantic proximity Read ↗

Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis.Semantic proximity Read ↗

Identification of Ten Additional Susceptibility Loci for Ulcerative Colitis Through Immunochip Analysis in Koreans.Semantic proximity Read ↗

Update on genetics in inflammatory disease.Semantic proximity Read ↗

Investigation of IL23R, JAK2, and STAT3 gene polymorphisms and gene-gene interactions in Crohn's disease and ulcerative colitis in a Turkish population.Semantic proximity Read ↗

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.Semantic proximity Read ↗

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility.Semantic proximity Read ↗

Genetic association between IL23R rs11209026 and rs10889677 polymorphisms and risk of Crohn's disease and ulcerative colitis: evidence from 41 studies.Semantic proximity Read ↗

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.Semantic proximity Read ↗

rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants.Semantic proximity Read ↗

Replication study of ulcerative colitis risk loci in a Lithuanian-Latvian case-control sample.Semantic proximity Read ↗

Genetics of inflammatory bowel disease: implications for disease pathogenesis and natural history.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.