Article
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility.
Nature genetics - 1 Nov 2008
Franke Andre, Balschun Tobias, Karlsen Tom H, Sventoraityte Jurgita, Nikolaus Susanna, Mayr Gabriele, Domingues Francisco S, Albrecht Mario, Nothnagel Michael, Ellinghaus David, Sina Christian, Onnie Clive M, Weersma Rinse K, Stokkers Pieter C F, Wijmenga Cisca, Gazouli Maria, Strachan David, McArdle Wendy L, Vermeire Séverine, Rutgeerts Paul, Rosenstiel Philip, Krawczak Michael, Vatn Morten H, Mathew Christopher G, Schreiber Stefan
Abstract excerpt
Inflammatory bowel disease (IBD) typically manifests as either ulcerative colitis (UC) or Crohn's disease (CD). Systematic identification of susceptibility genes for IBD has thus far focused mainly on CD, and little is known about the genetic architecture of UC. Here we report a genome-wide association study with 440,794 SNPs genotyped in 1,167 individuals with UC and 777 healthy controls. Twenty of the most...
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