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Article

Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).

Nature genetics - 1 Apr 2010

Franke Andre, Balschun Tobias, Sina Christian, Ellinghaus David, Häsler Robert, Mayr Gabriele, Albrecht Mario, Wittig Michael, Buchert Eva, Nikolaus Susanna, Gieger Christian, Wichmann H Erich, Sventoraityte Jurgita, Kupcinskas Limas, Onnie Clive M, Gazouli Maria, Anagnou Nicholas P, Strachan David, McArdle Wendy L, Mathew Christopher G, Rutgeerts Paul, Vermeire Séverine, Vatn Morten H, Krawczak Michael, Rosenstiel Philip, Karlsen Tom H, Schreiber Stefan

Abstract excerpt

We performed a genome-wide association analysis of 1,897,764 SNPs in 1,043 German ulcerative colitis (UC) cases and 1,703 controls. We discovered new associations at chromosome 7q22 (rs7809799) and at chromosome 22q13 in IL17REL (rs5771069) and confirmed these associations in six replication panels (2,539 UC cases and 5,428 controls) from different regions of Europe (overall study sample P(rs7809799) = 8.81 x...

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Share to Chromosomes, Human, Pair 22
Share to Chromosomes, Human, Pair 7
Share to Colitis, Ulcerative
Share to Genetic Predisposition to Disease
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Share to Polymorphism, Single Nucleotide
Share to Receptors, Interleukin-17
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Identifiers

PMID: 20228798
DOI: 10.1038/ng.553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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