Pooled Resequencing of 122 Ulcerative Colitis Genes in a Large Dutch Cohort Suggests Population-Specific Associations of Rare Variants in MUC2.

doi:10.1371/journal.pone.0159609

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Article

Pooled Resequencing of 122 Ulcerative Colitis Genes in a Large Dutch Cohort Suggests Population-Specific Associations of Rare Variants in MUC2.

PloS one - 1 Jan 2016

Visschedijk Marijn C, Alberts Rudi, Mucha Soren, Deelen Patrick, de Jong Dirk J, Pierik Marieke, Spekhorst Lieke M, Imhann Floris, van der Meulen-de Jong Andrea E, van der Woude C Janneke, van Bodegraven Adriaan A, Oldenburg Bas, Löwenberg Mark, Dijkstra Gerard, Ellinghaus David, Schreiber Stefan, Wijmenga Cisca, Rivas Manuel A, Franke Andre, van Diemen Cleo C, Weersma Rinse K

Abstract excerpt

Genome-wide association studies have revealed several common genetic risk variants for ulcerative colitis (UC). However, little is known about the contribution of rare, large effect genetic variants to UC susceptibility. In this study, we performed a deep targeted re-sequencing of 122 genes in Dutch UC patients in order to investigate the contribution of rare variants to the genetic susceptibility to UC. The...

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PMID: 27490946
DOI: 10.1371/journal.pone.0159609
PMCID: PMC4973970

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MUC2

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