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Article

Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease

27 Oct 2009

Abstract excerpt

BACKGROUND: Huntington's disease (HD) is an inherited neurogenerative disease caused by an abnormal expansion of glutamine repeats in the huntingtin protein. There is currently no treatment to prevent the neurodegeneration caused by this devastating disorder. Huntingtin has been shown to be a positive regulator of vesicular transport, particularly for neurotrophins such as brain-derived neurotrophic factor...

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PMID: 19860865
DOI: 10.1186/1756-6606-2-33

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Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's diseasePMID 19860865Read ↗

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