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Article

[Huntington's disease: cellular and molecular basis of pathology].

Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova - 1 Jan 2000

Korzhova V V, Artamonov D N, Vlasova O L, Bezprozvannyĭ I B

Abstract excerpt

Huntington's disease (HD) is an inherited autosomal dominant neurodegenerative disorder caused by a polyQ expansion (>36 glutamine repeats) in Huntingtin (Htt) protein. It is believed that dysfunction of corticostriatal system is one of the main pathological events. Special attention is paid to synaptic dysfunction of transmission between cortical and striatal neurons. This review focuses on modern concepts of...

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PMID: 25723022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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