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Article

Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Feb 2006

Pardo Raúl, Colin Emilie, Régulier Etienne, Aebischer Patrick, Déglon Nicole, Humbert Sandrine, Saudou Frédéric

Abstract excerpt

Huntington's disease (HD) is caused by an abnormal expanded polyglutamine (polyQ) repeat in the huntingtin protein. Insulin-like growth factor-1 acting through the prosurvival kinase Akt mediates the phosphorylation of huntingtin at S421 and inhibits the toxicity of polyQ-expanded huntingtin in cell culture, suggesting that compounds enhancing phosphorylation are of therapeutic interest. However, it is not clear...

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Identifiers

PMID: 16452687
DOI: 10.1523/JNEUROSCI.3706-05.2006
PMCID: PMC6675484

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.PMID 16452687Read ↗

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