Reduced calcineurin protein levels and activity in exon-1 mouse models of Huntington's disease: role in excitotoxicity.

doi:10.1016/j.nbd.2009.08.012

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Reduced calcineurin protein levels and activity in exon-1 mouse models of Huntington's disease: role in excitotoxicity.

Neurobiology of disease - 1 Dec 2009

Xifró Xavier, Giralt Albert, Saavedra Ana, García-Martínez Juan M, Díaz-Hernández Miguel, Lucas José J, Alberch Jordi, Pérez-Navarro Esther

Abstract excerpt

Calcineurin is a serine/threonine phosphatase involved in the regulation of glutamate receptors signaling. Here, we analyzed whether the regulation of calcineurin protein levels and activity modulates the susceptibility of striatal neurons to excitotoxicity in R6/1 and R6/1:BDNF+/- mouse models of Huntington's disease. We show that calcineurin inhibition in wild-type mice drastically reduced quinolinic...

Topics

Adult
Aged
Animals
Brain
Brain-Derived Neurotrophic Factor
Calcineurin
Calcineurin Inhibitors
Cell Death
Disease Models, Animal
Disease Progression
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Huntingtin Protein

Huntington Disease

Mice

Mice, Transgenic

Middle Aged

Mutation

Nerve Tissue Proteins

Source

Open in PubMed

Identifiers

PMID: 19733666
DOI: 10.1016/j.nbd.2009.08.012

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduced calcineurin protein levels and activity in exon-1 mouse models of Huntington's disease: role in excitotoxicity.PMID 19733666Read ↗

Disruption of striatal glutamatergic transmission induced by mutant huntingtin involves remodeling of both postsynaptic density and NMDA receptor signaling.Semantic proximity Read ↗

Calcineurin inhibitors cause an acceleration of the neurological phenotype in a mouse transgenic for the human Huntington's disease mutation.Semantic proximity Read ↗

Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's diseaseSemantic proximity Read ↗

Calcineurin is involved in the early activation of NMDA-mediated cell death in mutant huntingtin knock-in striatal cells.Semantic proximity Read ↗

Regulator of Calcineurin (RCAN1-1L) Is Deficient in Huntington Disease and Protective against Mutant Huntingtin Toxicity in VitroSemantic proximity Read ↗

Striatal synaptic dysfunction and altered calcium regulation in Huntington diseaseSemantic proximity Read ↗

Alterations of Calcium Channels in a Mouse Model of Huntington’s Disease and Neuroprotection by Blockage of Ca V 1 ChannelsSemantic proximity Read ↗

Altered excitability and exocytosis in chromaffin cells from the R6/1 mouse model of Huntington's disease is linked to over-expression of mutated huntingtin.Semantic proximity Read ↗

Brain-derived neurotrophic factor over-expression in the forebrain ameliorates Huntington's disease phenotypes in mice.Semantic proximity Read ↗

Calcineurin-mediated regulation of growth-associated protein 43 is essential for neurite and synapse formation and protects against α-synuclein-induced degenerationSemantic proximity Read ↗

Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutation.Semantic proximity Read ↗

Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.