Article

Calcineurin-mediated regulation of growth-associated protein 43 is essential for neurite and synapse formation and protects against α-synuclein-induced degeneration

2025-01-16

Abstract excerpt

<h4>Introduction</h4> Elevated calcium (Ca 2+ ) levels and hyperactivation of the Ca 2+ -dependent phosphatase calcineurin are key factors in α-synuclein (α-syn) pathobiology in Dementia with Lewy Bodies and Parkinson’s Disease (PD). Calcineurin activity can be inhibited by FK506, an FDA-approved compound. Our previous work demonstrated that sub-saturating doses of FK506 provide neuroprotection against α-syn pa...

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Literature Corpus work: 84f4a2d6-b529-5023-8e19-0cfc3e3b104a
DOI: 10.1101/2025.01.13.632848

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