Article
Targeting Gpr52 lowers mutant HTT levels and rescues Huntington's disease-associated phenotypes.
Brain : a journal of neurology - 1 Jun 2018
Song Haikun, Li Hexuan, Guo Shimeng, Pan Yuyin, Fu Yuhua, Zhou Zijian, Li Zhaoyang, Wen Xue, Sun Xiaoli, He Bingqing, Gu Haifeng, Zhao Quan, Wang Cen, An Ping, Luo Shouqing, Hu Youhong, Xie Xin, Lu Boxun
Abstract excerpt
See Huang and Gitler (doi:10.1093/brain/awy112) for a scientific commentary on this article.Lowering the levels of disease-causing proteins is an attractive treatment strategy for neurodegenerative disorders, among which Huntington's disease is an appealing disease for testing this strategy because of its monogenetic nature. Huntington's disease is mainly caused by cytotoxicity of the mutant HTT protein with an...
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