Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis.

Cellular and molecular life sciences : CMLS - 1 Jan 2010

Reekmans Sara M, Pflanzner Thorsten, Gordts Philip L S M, Isbert Simone, Zimmermann Pascale, Annaert Wim, Weggen Sascha, Roebroek Anton J M, Pietrzik Claus U

Abstract excerpt

The proximal NPXY and distal NPXYXXL motifs in the intracellular domain of LRP1 play an important role in regulation of the function of the receptor. The impact of single and double inactivating knock-in mutations of these motifs on receptor maturation, cell surface expression, and ligand internalization was analyzed in mutant and control wild-type mice and MEFs. Single inactivation of the proximal NPXY or in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Embryonic Development

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endocytosis

Share to Gene Knock-In Techniques

Share to Low Density Lipoprotein Receptor-Related Protein-1

Share to Proteasome Endopeptidase Complex

Share to Protein Interaction Domains and Motifs

Share to Receptors, LDL

Source

Open in PubMed Open full text

Identifiers

PMID: 19856143
DOI: 10.1007/s00018-009-0171-7
PMCID: PMC11115674

Genes

LRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis.PMID 19856143Read ↗

Mutant Lrp1 knock-in mice generated by recombinase-mediated cassette exchange reveal differential importance of the NPXY motifs in the intracellular domain of LRP1 for normal fetal development.Semantic proximity Read ↗

Inactivation of the LRP1 intracellular NPxYxxL motif in LDLR-deficient mice enhances postprandial dyslipidemia and atherosclerosis.Semantic proximity Read ↗

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.Semantic proximity Read ↗

A tyrosine-based sorting signal regulates intracellular trafficking of protease-activated receptor-1: multiple regulatory mechanisms for agonist-induced G protein-coupled receptor internalization.Semantic proximity Read ↗

Nbr1 is a novel inhibitor of ligand-mediated receptor tyrosine kinase degradation.Semantic proximity Read ↗

Functional expression of murine LRP1 requires correction of Lrp1 cDNA sequences.Semantic proximity Read ↗

Cutting edge: A double-mutant knockin of the CD28 YMNM and PYAP motifs reveals a critical role for the YMNM motif in regulation of T cell proliferation and Bcl-xL expression.Semantic proximity Read ↗

Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo.Semantic proximity Read ↗

The dileucine motif within the tail of MPR46 is required for sorting of the receptor in endosomes.Semantic proximity Read ↗

Characterization of a di-leucine-based signal in the cytoplasmic tail of the nucleotide-pyrophosphatase NPP1 that mediates basolateral targeting but not endocytosis.Semantic proximity Read ↗

Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.Semantic proximity Read ↗

Internalization of the alpha 5 beta 1 integrin does not depend on "NPXY" signals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.