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Article

Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.

Molecular and cellular biology - 1 May 2004

Marschang Peter, Brich Jochen, Weeber Edwin J, Sweatt J David, Shelton John M, Richardson James A, Hammer Robert E, Herz Joachim

Abstract excerpt

LRP1b and the closely related LRP1 are large members of the low-density lipoprotein receptor family. At the protein level LRP1b is 55% identical to LRP1, a multifunctional and developmentally essential receptor with roles in cargo transport and cellular signaling. Somatic LRP1b mutations frequently occur in non-small cell lung cancer and urothelial cancers, suggesting a role in the modulation of cellular growth....

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Source

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Identifiers

PMID: 15082773
DOI: 10.1128/MCB.24.9.3782-3793.2004
PMCID: PMC387731

Genes

LRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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