Article
Mutant Lrp1 knock-in mice generated by recombinase-mediated cassette exchange reveal differential importance of the NPXY motifs in the intracellular domain of LRP1 for normal fetal development.
Molecular and cellular biology - 1 Jan 2006
Roebroek Anton J M, Reekmans Sara, Lauwers Annick, Feyaerts Nathalie, Smeijers Liesbet, Hartmann Dieter
Abstract excerpt
Lrp1 knock-in mice carrying either a wild-type allele or three different mutated alleles encoding the multifunctional endocytic receptor LRP1 were generated by recombinase-mediated cassette exchange (RMCE). Reinsertion by RMCE of a wild-type allele led to a normal pattern and level of gene expression and a completely normal phenotype, indicating that the RMCE procedure itself is neutral with respect to the...
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