Nbr1 is a novel inhibitor of ligand-mediated receptor tyrosine kinase degradation.

doi:10.1128/MCB.00878-10

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Article

Nbr1 is a novel inhibitor of ligand-mediated receptor tyrosine kinase degradation.

Molecular and cellular biology - 1 Dec 2010

Mardakheh Faraz K, Auciello Giulio, Dafforn Tim R, Rappoport Joshua Z, Heath John K

Abstract excerpt

Neighbor of BRCA1 (Nbr1) is a highly conserved multidomain scaffold protein with proposed roles in endocytic trafficking and selective autophagy. However, the exact function of Nbr1 in these contexts has not been studied in detail. Here we investigated the role of Nbr1 in the trafficking of receptor tyrosine kinases (RTKs). We report that ectopic Nbr1 expression inhibits the ligand-mediated lysosomal degradation...

Topics

Amino Acid Sequence
Animals
Cell Line
Endocytosis
Endosomes
Humans
Intracellular Signaling Peptides and Proteins
Ligands
Lysosomes
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Protein Structure, Tertiary

Proteins

Receptor Protein-Tyrosine Kinases

Recombinant Fusion Proteins

Sequence Alignment

Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 20937771
DOI: 10.1128/MCB.00878-10
PMCID: PMC3004269

Genes

BRCA1
NBR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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