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Article

Inactivation of the LRP1 intracellular NPxYxxL motif in LDLR-deficient mice enhances postprandial dyslipidemia and atherosclerosis.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2009

Gordts Philip L S M, Reekmans Sara, Lauwers Annick, Van Dongen Amber, Verbeek Leen, Roebroek Anton J M

Abstract excerpt

OBJECTIVE: The purpose of this study was to determine the significance of the intracellular NPxYxxL motif of LRP1 for the atheroprotective role of this multifunctional receptor. METHODS AND RESULTS: LRP1 knock-in mice carrying an inactivating mutation in the NPxYxxL motif were crossed with LDLR-deficient mice, a model for atherosclerosis. In this LDLR(-/-) background the mutated mice showed a more atherogenic...

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Source

Identifiers

PMID: 19667105
DOI: 10.1161/ATVBAHA.109.192211

Genes

LRP1
LDLR
MMP2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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