Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased rate of human mutations where DNA and RNA polymerases collide.

Trends in genetics : TIG - 1 Dec 2009

Jørgensen Frank Grønlund, Schierup Mikkel H

Abstract excerpt

Gene density and orientation of genes in eukaryotes seem to be correlated with the replication origin and the mutation rate is greater in late replicating regions; however, the reason for these patterns is unknown. Here, we investigate predicted replication origins in the human genome and find that levels of polymorphism as well as divergence from the chimpanzee genome are greater in genes transcribed on the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Evolution
Share to DNA-Directed DNA Polymerase
Share to DNA-Directed RNA Polymerases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Replication Origin

Source

Identifiers

PMID: 19853958
DOI: 10.1016/j.tig.2009.10.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased rate of human mutations where DNA and RNA polymerases collide.PMID 19853958Read ↗

The Genomic Architecture of Human DNA Replication OriginsSemantic proximity Read ↗

Replication origins drive genetic and phenotypic variation in humansSemantic proximity Read ↗

Polymerase ζ activity is linked to replication timing in humans: evidence from mutational signaturesSemantic proximity Read ↗

Replication-associated mutational asymmetry in the human genome.Semantic proximity Read ↗

Differential relationship of DNA replication timing to different forms of human mutation and variation.Semantic proximity Read ↗

Lagging-strand replication shapes the mutational landscape of the genome.Semantic proximity Read ↗

The evolution of the human DNA replication timing programSemantic proximity Read ↗

Orientation, distance, regulation and function of neighbouring genes.Semantic proximity Read ↗

Distinct contributions of replication and transcription to mutation rate variation of human genomes.Semantic proximity Read ↗

Global landscape of replicative DNA polymerase usage in the human genomeSemantic proximity Read ↗

Transcription-induced mutation and ancient gBGC shape the evolution of human transcriptional start sitesSemantic proximity Read ↗

Transcription induces strand-specific mutations at the 5' end of human genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.