Transcription induces strand-specific mutations at the 5' end of human genes.

doi:10.1101/gr.076570.108

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Article

Transcription induces strand-specific mutations at the 5' end of human genes.

Genome research - 1 Aug 2008

Polak Paz, Arndt Peter F

Abstract excerpt

A regional analysis of nucleotide substitution rates along human genes and their flanking regions allows us to quantify the effect of mutational mechanisms associated with transcription in germ line cells. Our analysis reveals three distinct patterns of substitution rates. First, a sharp decline in the deamination rate of methylated CpG dinucleotides, which is observed in the vicinity of the 5' end of genes....

Topics

5' Flanking Region
Animals
CpG Islands
DNA
Embryonic Stem Cells
Genomics
Humans
Introns
Macaca mulatta
Mutation
Nucleotides
Pan troglodytes
Transcription Initiation Site
Transcription, Genetic

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Identifiers

PMID: 18463301
DOI: 10.1101/gr.076570.108
PMCID: PMC2493432

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