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Article

Drosophila KDM2 is a H3K4me3 demethylase regulating nucleolar organization

1 Jan 2009

Abstract excerpt

BACKGROUND: CG11033 (dKDM2) is the Drosophila homolog of the gene KDM2B. dKDM2 has been known to possess histone lysine demethylase activity towards H3K36me2 in cell lines and it regulates H2A ubiquitination. The human homolog of the gene has dual activity towards H3K36me2 as well as H3K4me3, and plays an important role in cellular senescence. FINDINGS: We have used transgenic flies bearing an RNAi construct for...

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PMID: 19852816
DOI: 10.1186/1756-0500-2-217

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