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Article

Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death.

Circulation research - 4 Dec 2009

Qian Jiang, Ren Xiaoping, Wang Xiaohong, Zhang Pengyuan, Jones W Keith, Molkentin Jeffery D, Fan Guo-Chang, Kranias Evangelia G

Abstract excerpt

RATIONALE: The levels of a small heat shock protein (Hsp)20 and its phosphorylation are increased on ischemic insults, and overexpression of Hsp20 protects the heart against ischemia/reperfusion injury. However, the mechanism underlying cardioprotection of Hsp20 and especially the role of its phosphorylation in regulating ischemia/reperfusion-induced autophagy, apoptosis, and necrosis remain to be clarified....

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Source

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Identifiers

PMID: 19850943
DOI: 10.1161/CIRCRESAHA.109.200378
PMCID: PMC2799045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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