Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Localization of phosphorylated alphaB-crystallin to heart mitochondria during ischemia-reperfusion.

American journal of physiology. Heart and circulatory physiology - 1 Jan 2008

Jin J-K, Whittaker R, Glassy M S, Barlow S B, Gottlieb R A, Glembotski C C

Abstract excerpt

The cytosolic small heat shock protein alphaB-crystallin (alphaBC) is a molecular chaperone expressed in large quantities in the heart, where it protects from stresses such as ischemia-reperfusion (I/R). Upon I/R, p38 MAP kinase activation leads to phosphorylation of alphaBC on Ser(59) (P-alphaBC-S59), which increases its protective ability. alphaBC confers protection, in part, by interacting with and affecting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Crystallin B Chain
Share to Imidazoles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitochondria, Heart

Share to Mitochondrial Membrane Transport Proteins

Share to Myocardial Reperfusion Injury

Share to p38 Mitogen-Activated Protein Kinases

Share to Pyridines

Share to Subcellular Fractions

Source

Identifiers

PMID: 17993600
DOI: 10.1152/ajpheart.00881.2007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Localization of phosphorylated alphaB-crystallin to heart mitochondria during ischemia-reperfusion.PMID 17993600Read ↗

Roles for alphaB-crystallin and HSPB2 in protecting the myocardium from ischemia-reperfusion-induced damage in a KO mouse model.Semantic proximity Read ↗

Myopathy-associated alphaB-crystallin mutants: abnormal phosphorylation, intracellular location, and interactions with other small heat shock proteins.Semantic proximity Read ↗

Phosphorylation of CRYAB Induces a Condensatopathy to Worsen Post-Myocardial Infarction Left Ventricular RemodelingSemantic proximity Read ↗

Protein Kinase N Promotes Stress-Induced Cardiac Dysfunction Through Phosphorylation of Myocardin-Related Transcription Factor A and Disruption of Its Interaction With ActinSemantic proximity Read ↗

Mutations in the Txnip PPXY motifs protect against myocardial infarction despite enhanced protein stability.Semantic proximity Read ↗

The Cardioprotective PKA-Mediated Hsp20 Phosphorylation Modulates Protein Associations Regulating Cytoskeletal Dynamics.Semantic proximity Read ↗

Specific regulation of noncanonical p38alpha activation by Hsp90-Cdc37 chaperone complex in cardiomyocyte.Semantic proximity Read ↗

Txnip C247S mutation protects the heart against acute myocardial infarction.Semantic proximity Read ↗

Role of RyR2 phosphorylation at S2814 during heart failure progression.Semantic proximity Read ↗

Abundance and Location of the Small Heat Shock Proteins HSP25 and αB-Crystallin in Rat and Human HeartSemantic proximity Read ↗

Cys340Ser Mutation Abolishing S-Nitrosylation Drives GRK2 Mitochondrial Localization and Dysfunction.Semantic proximity Read ↗

Mutation of a single cysteine in CaMKIIδ protects the heart from ischemia-reperfusion InjurySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.