Article

Ser14-RPN6 Phosphorylation Mediates the Activation of 26S Proteasomes by cAMP and Protects against Cardiac Proteotoxic Stress in Mice

2023-04-06

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> A better understanding of the regulation of proteasome activities can facilitate the search for new therapeutic strategies. A cell culture study shows that cAMP-dependent protein kinase (PKA) activates the 26S proteasome by phosphorylating Ser14 of RPN6 (pS14-RPN6), but this discovery and its physiological significance remain to be established in vivo . <h4>Methods</h4> M...

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Literature Corpus work: 0e38eade-be69-5231-b103-b2d962af0c43
DOI: 10.1101/2023.04.05.535705

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