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Article

The Cardioprotective PKA-Mediated Hsp20 Phosphorylation Modulates Protein Associations Regulating Cytoskeletal Dynamics.

International journal of molecular sciences - 16 Dec 2020

Vafiadaki Elizabeth, Arvanitis Demetrios A, Eliopoulos Aristides G, Kranias Evangelia G, Sanoudou Despina

Abstract excerpt

The cytoskeleton has a primary role in cardiomyocyte function, including the response to mechanical stimuli and injury. The small heat shock protein 20 (Hsp20) conveys protective effects in cardiac muscle that are linked to serine-16 (Ser16) Hsp20 phosphorylation by stress-induced PKA, but the link between Hsp20 and the cytoskeleton remains poorly understood. Herein, we demonstrate a physical and functional...

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Identifiers

PMID: 33339131
DOI: 10.3390/ijms21249572
PMCID: PMC7765622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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