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Article

Interruption of CryAB-amyloid oligomer formation by HSP22.

The Journal of biological chemistry - 5 Jan 2007

Sanbe Atsushi, Yamauchi Junji, Miyamoto Yuki, Fujiwara Yoko, Murabe Mayu, Tanoue Akito

Abstract excerpt

An R120G missense mutation in alpha-B-crystallin (CryAB), a small heat-shock protein (HSP), causes a desmin-related cardiomyopathy (DRM) that is characterized by the formation of aggregates containing CryAB and desmin. The mutant CryAB protein leads to the formation of inclusion bodies, which contain amyloid oligomer intermediates (amyloid oligomer) in the cardiomyocytes. To further address the underlying...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17092938
DOI: 10.1074/jbc.M605481200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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