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Article

Overexpression of Heat Shock Protein 70 Improves Cardiac Remodeling and Survival in Protein Phosphatase 2A-Expressing Transgenic Mice with Chronic Heart Failure.

Cells - 15 Nov 2021

Yoon Somy, Gergs Ulrich, McMullen Julie R, Eom Gwang Hyeon

Abstract excerpt

Heat shock protein (HSP) 70 is a molecular chaperone that regulates protein structure in response to thermal stress. In addition, HSP70 is involved in post-translational modification and is related to the severity of some diseases. Here, we tested the functional relevance of long-lasting HSP70 expression in a model of nonischemic heart failure using protein phosphatase 2 catalytic subunit A (PP2CA)-expressing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34831402
DOI: 10.3390/cells10113180
PMCID: PMC8624068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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