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Article

European population substructure correlates with systemic lupus erythematosus endophenotypes in North Americans of European descent.

Genes and immunity - 1 Sept 2010

Richman I B, Chung S A, Taylor K E, Kosoy R, Tian C, Ortmann W A, Nititham J, Lee A T, Rutman S, Petri M, Manzi S, Behrens T W, Gregersen P K, Seldin M F, Criswell L A

Abstract excerpt

Previous work has demonstrated that Northern and Southern European ancestries are associated with specific systemic lupus erythematosus (SLE) manifestations. In this study, 1855 SLE cases of European descent were genotyped for 4965 single-nucleotide polymorphisms and principal components analysis of genotype information was used to define population substructure. The first principal component (PC1) distinguished...

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Identifiers

PMID: 19847193
DOI: 10.1038/gene.2009.80
PMCID: PMC3951966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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