Article
Discerning the ancestry of European Americans in genetic association studies.
PLoS genetics - 1 Jan 2008
Price Alkes L, Butler Johannah, Patterson Nick, Capelli Cristian, Pascali Vincenzo L, Scarnicci Francesca, Ruiz-Linares Andres, Groop Leif, Saetta Angelica A, Korkolopoulou Penelope, Seligsohn Uri, Waliszewska Alicja, Schirmer Christine, Ardlie Kristin, Ramos Alexis, Nemesh James, Arbeitman Lori, Goldstein David B, Reich David, Hirschhorn Joel N
Abstract excerpt
European Americans are often treated as a homogeneous group, but in fact form a structured population due to historical immigration of diverse source populations. Discerning the ancestry of European Americans genotyped in association studies is important in order to prevent false-positive or false-negative associations due to population stratification and to identify genetic variants whose contribution to disease...
Topics
- Bipolar Disorder
- Case-Control Studies
- DNA
- Genetic Markers
- Genetic Variation
- Genetics, Population
- Genome, Human
- Geography
- Humans