Article
Contrasting patterns of Y chromosome variation in Ashkenazi Jewish and host non-Jewish European populations.
Human genetics - 1 Mar 2004
Behar Doron M, Garrigan Daniel, Kaplan Matthew E, Mobasher Zahra, Rosengarten Dror, Karafet Tatiana M, Quintana-Murci Lluis, Ostrer Harry, Skorecki Karl, Hammer Michael F
Abstract excerpt
The molecular basis of more than 25 genetic diseases has been described in Ashkenazi Jewish populations. Most of these diseases are characterized by one or two major founder mutations that are present in the Ashkenazi population at elevated frequencies. One explanation for this preponderance of recessive diseases is accentuated genetic drift resulting from a series of dispersals to and within Europe, endogamy,...
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