Bias in effect size of systemic lupus erythematosus susceptibility loci across Europe: a case-control study.

doi:10.1186/ar3818

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Article

Bias in effect size of systemic lupus erythematosus susceptibility loci across Europe: a case-control study.

Arthritis research & therapy - 27 Apr 2012

Alonso-Perez Elisa, Suarez-Gestal Marian, Calaza Manuel, Sebastiani Gian Domenico, Pullmann Rudolf, Papasteriades Chryssa, Kovacs Attila, Skopouli Fotini N, Bijl Marc, Suarez Ana, Marchini Maurizio, Migliaresi Sergio, Carreira Patricia, Ordi-Ros Josep, Witte Torsten, Ruzickova Sarka, Santos Maria Jose, Barizzone Nadia, Blanco Francisco J, Lauwerys Bernard R, Gomez-Reino Juan J, Gonzalez Antonio

Abstract excerpt

INTRODUCTION: We aimed to investigate whether the effect size of the systemic lupus erythematosus (SLE) risk alleles varies across European subpopulations. METHODS: European SLE patients (n = 1,742) and ethnically matched healthy controls (n = 2,101) were recruited at 17 centres from 10 different countries. Only individuals with self-reported ancestry from the country of origin were included. In addition,...

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PMID: 22541939
DOI: 10.1186/ar3818
PMCID: PMC3446468

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