Article
Defining the role of the MHC in autoimmunity: a review and pooled analysis.
PLoS genetics - 25 Apr 2008
Fernando Michelle M A, Stevens Christine R, Walsh Emily C, De Jager Philip L, Goyette Philippe, Plenge Robert M, Vyse Timothy J, Rioux John D
Abstract excerpt
The major histocompatibility complex (MHC) is one of the most extensively studied regions in the human genome because of the association of variants at this locus with autoimmune, infectious, and inflammatory diseases. However, identification of causal variants within the MHC for the majority of these diseases has remained difficult due to the great variability and extensive linkage disequilibrium (LD) that...
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