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Article

Modulation of alpha interferon anti-hepatitis C virus activity by ISG15

3 Nov 2009

Abstract excerpt

ISG15 has recently been reported to possess antiviral properties against viruses, both in vivo and in vitro. Knock-down of ISG15 gene expression by small interfering RNA followed by alpha interferon (IFN-alpha) treatment in Huh-7 cells resulted in an increased phenotypic sensitivity to IFN-alpha, as determined by measuring hepatitis C virus (HCV) RNA replication inhibition in stably transfected HCV replicon cells...

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PMID: 19656964
DOI: 10.1099/vir.0.013128-0

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