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Article

Disappearance of the budding yeast Bub2-Bfa1 complex from the mother-bound spindle pole contributes to mitotic exit.

The Journal of cell biology - 30 Jan 2006

Fraschini Roberta, D'Ambrosio Claudio, Venturetti Marianna, Lucchini Giovanna, Piatti Simonetta

Abstract excerpt

Budding yeast spindle position checkpoint is engaged by misoriented spindles and prevents mitotic exit by inhibiting the G protein Tem1 through the GTPase-activating protein (GAP) Bub2/Bfa1. Bub2 and Bfa1 are found on both duplicated spindle pole bodies until anaphase onset, when they disappear from the mother-bound spindle pole under unperturbed conditions. In contrast, when spindles are misoriented they remain...

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Identifiers

PMID: 16449187
DOI: 10.1083/jcb.200507162
PMCID: PMC2063644

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Disappearance of the budding yeast Bub2-Bfa1 complex from the mother-bound spindle pole contributes to mitotic exit.PMID 16449187Read ↗

Different levels of Bfa1/Bub2 GAP activity are required to prevent mitotic exit of budding yeast depending on the type of perturbations.Semantic proximity Read ↗

The Bfa1/Bub2 GAP complex comprises a universal checkpoint required to prevent mitotic exit.Semantic proximity Read ↗

The C-terminus of Bfa1p in budding yeast is essential to induce mitotic arrest in response to diverse checkpoint-activating signals.Semantic proximity Read ↗

Modes of spindle pole body inheritance and segregation of the Bfa1p-Bub2p checkpoint protein complex.Semantic proximity Read ↗

Cdc5-dependent asymmetric localization of bfa1 fine-tunes timely mitotic exit.Semantic proximity Read ↗

The MEN mediates the effects of the spindle assembly checkpoint on Kar9-dependent spindle pole body inheritance in budding yeast.Semantic proximity Read ↗

The Bub2-dependent mitotic pathway in yeast acts every cell cycle and regulates cytokinesis.Semantic proximity Read ↗

Bub3p facilitates spindle checkpoint silencing in fission yeast.Semantic proximity Read ↗

Septins have a dual role in controlling mitotic exit in budding yeast.Semantic proximity Read ↗

Bfa1 can regulate Tem1 function independently of Bub2 in the mitotic exit network of Saccharomyces cerevisiae.Semantic proximity Read ↗

Saccharomyces cerevisiae BUB2 prevents mitotic exit in response to both spindle and kinetochore damage.Semantic proximity Read ↗

Temporal coupling of spindle disassembly and cytokinesis is disrupted by deletion of LTE1 in budding yeast.Semantic proximity Read ↗

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