Schizosaccharomyces pombe Bub3 is dispensable for mitotic arrest following perturbed spindle formation.

doi:10.1534/genetics.107.081695

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Article

Schizosaccharomyces pombe Bub3 is dispensable for mitotic arrest following perturbed spindle formation.

Genetics - 1 Jun 2008

Tange Yoshie, Niwa Osami

Abstract excerpt

The core proteins of the spindle assembly checkpoint (SAC), Mads, Bubs, and Mps1, first identified in the budding yeast, are thought to be functionally and structurally conserved through evolution. We found that fission yeast Bub3 is dispensable for SAC, as bub3 null mutants blocked mitotic progression when spindle formation was disrupted. Consistently, the bub3 mutation only weakly affected the stability of...

Topics

Cell Cycle Proteins
Chromosomal Instability
Chromosomal Proteins, Non-Histone
Chromosomes, Fungal
Genes, Fungal
Mitosis
Mutation
Nuclear Proteins
Phosphoproteins
Schizosaccharomyces
Schizosaccharomyces pombe Proteins
Spindle Apparatus
Cohesins

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Identifiers

PMID: 18505884
DOI: 10.1534/genetics.107.081695
PMCID: PMC2429874

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