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Article

The spontaneous Ala147Thr amino acid substitution within the translocator protein influences pregnenolone production in lymphomonocytes of healthy individuals.

Endocrinology - 1 Dec 2009

Costa Barbara, Pini Stefano, Gabelloni Pamela, Da Pozzo Eleonora, Abelli Marianna, Lari Lisa, Preve Matteo, Lucacchini Antonio, Cassano Giovanni B, Martini Claudia

Abstract excerpt

The de novo production of steroids and neurosteroids begins in mitochondria by the conversion of cholesterol to pregnenolone through cytochrome P450 side-chain cleavage (CYP11A1) enzymatic activity. The C-terminal amino acid domain of the translocator protein (TSPO) has been demonstrated to bind cholesterol, thereby determining its mitochondrial translocation. The goal of the present study was to investigate the...

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Source

Identifiers

PMID: 19846611
DOI: 10.1210/en.2009-0752

Genes

TSPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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