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Article

Role of translocator protein (18 kDa) in adult separation anxiety and attachment style in patients with depression.

Current molecular medicine - 1 May 2012

Costa B, Pini S, Abelli M, Gabelloni P, Da Pozzo E, Chelli B, Calugi S, Lari L, Cardini A, Lucacchini A, Cassano G B, Martini C

Abstract excerpt

BACKGROUND AND OBJECTIVES: A role for the protein that mediates the rate-limiting step of steroidogenesis, the 18 kDa Translocator Protein (TSPO), has been suggested in the pathophysiology of Adult Separation Anxiety Disorder (ASAD). It has been shown that ASAD patients have 1) low TSPO expression levels and 2) a high frequency of the allele that substitutes Ala with Thr at position 147 of TSPO. The Thr147...

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Source

Identifiers

PMID: 22348616

Genes

TSPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Role of translocator protein (18 kDa) in adult separation anxiety and attachment style in patients with depression.PMID 22348616Read ↗

The spontaneous Ala147Thr amino acid substitution within the translocator protein influences pregnenolone production in lymphomonocytes of healthy individuals.Semantic proximity Read ↗

Bipolar Disorder is associated with the rs6971 polymorphism in the gene encoding 18 kDa Translocator Protein (TSPO).Semantic proximity Read ↗

Variation rs6971 in the Translocator Protein Gene (TSPO) is Associated with Aggressiveness and Impulsivity but Not with Anxiety in a Population-Representative Sample of Young Adults.Semantic proximity Read ↗

TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis.Semantic proximity Read ↗

Stress sensitivity in patients with atopic dermatitis in relation to the translocator protein 18 kDa (TSPO).Semantic proximity Read ↗

Mutation analysis of oxytocin gene in individuals with adult separation anxiety.Semantic proximity Read ↗

Oxytocin receptor and G-protein polymorphisms in patients with depression and separation anxiety.Semantic proximity Read ↗

Translocator protein and steroidogenesisSemantic proximity Read ↗

Differential mitochondrial protein interaction profile between human translocator protein and its <i>A147T</i> polymorphism variantSemantic proximity Read ↗

Functional TSPO polymorphism predicts variance in the diurnal cortisol rhythm in bipolar disorder.Semantic proximity Read ↗

An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28.Semantic proximity Read ↗

The Low-Affinity Binding of Second Generation Radiotracers Targeting TSPO is Associated with a Unique Allosteric Binding Site.Semantic proximity Read ↗

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