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Article

Genetic variants of SLCO1B7 are of relevance for the transport function of OATP1B3-1B7.

Pharmacological research - 1 Nov 2020

Meyer Zu Schwabedissen Henriette E, Seibert Isabell, Grube Markus, Alter Claudio L, Siegmund Werner, Hussner Janine

Abstract excerpt

The family of Organic Anion Transporting Polypeptides are known to facilitate the transmembrane transport. OATP1B3-1B7 is a novel member of the OATP1B-subfamily, and is encoded by SLCO1B3-SLCO1B7 readthrough deriving from the genes SLCO1B3 and SLCO1B7 on chromosome 12. The resulting protein is expressed in the smooth endoplasmatic reticulum of hepatocytes, is functional, and transports...

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PMID: 32818652
DOI: 10.1016/j.phrs.2020.105155

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