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Article

Translocator protein and steroidogenesis

6 Mar 2018

Abstract excerpt

Two interesting papers by Barren et al. and Owen et al. have been very recently published in Biochemical Journal, reporting the role of translocator protein (TSPO) in steroidogenesis. The involvement of TSPO in the steroid biosynthesis has been suggested by 30 years of researches, using biochemical, pharmacological and genetic experimental approaches. In the last 3 years, however, the TSPO involvement in...

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PMID: 29511094
DOI: 10.1042/bcj20170766

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Translocator protein and steroidogenesisPMID 29511094Read ↗

TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis.Semantic proximity Read ↗

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Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis.Semantic proximity Read ↗

CRISPR/Cas9‒Mediated Tspo Gene Mutations Lead to Reduced Mitochondrial Membrane Potential and Steroid Formation in MA-10 Mouse Tumor Leydig Cells.Semantic proximity Read ↗

Thirty years of StAR gazing. Expanding the universe of the steroidogenic acute regulatory proteinSemantic proximity Read ↗

Translocator protein ligand Ro5-4864 promotes melanogenesis in a TSPO independent mannerSemantic proximity Read ↗

Variation rs6971 in the Translocator Protein Gene (TSPO) is Associated with Aggressiveness and Impulsivity but Not with Anxiety in a Population-Representative Sample of Young Adults.Semantic proximity Read ↗

Guwiyang Wurra--'Fire Mouse': a global gene knockout model for TSPO/PBR drug development, loss-of-function and mechanisms of compensation studies.Semantic proximity Read ↗

The spontaneous Ala147Thr amino acid substitution within the translocator protein influences pregnenolone production in lymphomonocytes of healthy individuals.Semantic proximity Read ↗

Global Deletion of TSPO Does Not Affect the Viability and Gene Expression Profile.Semantic proximity Read ↗

Bipolar Disorder is associated with the rs6971 polymorphism in the gene encoding 18 kDa Translocator Protein (TSPO).Semantic proximity Read ↗

Mutation in the Trapalpha/Ssr1 gene, encoding translocon-associated protein alpha, results in outflow tract morphogenetic defects.Semantic proximity Read ↗

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