Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Cytomegalovirus Induces the Interferon Response via the DNA Sensor ZBP1

22 Oct 2009

Abstract excerpt

Human cytomegalovirus (HCMV) is a member of the betaherpesvirus family that, unlike other herpesviruses, triggers a strong innate immune response in infected cells that includes transcription of the beta interferon gene via activation of interferon regulatory factor 3 (IRF3). IRF3 activation requires signaling from pattern recognition receptors that is initiated by their interaction with specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Herpesvirus Infections and Treatments
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19846511
DOI: 10.1128/jvi.01748-09

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Cytomegalovirus Induces the Interferon Response via the DNA Sensor ZBP1PMID 19846511Read ↗

The zinc finger antiviral protein ZAP destabilises viral transcripts and restricts human cytomegalovirusSemantic proximity Read ↗

ZBP1: A Powerful Innate Immune Sensor and Double-Edged Sword in Host ImmunitySemantic proximity Read ↗

ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune responseSemantic proximity Read ↗

Who’s Driving? Human Cytomegalovirus, Interferon, and NFκB SignalingSemantic proximity Read ↗

Emerging Role of ZBP1 in Z-RNA Sensing, Influenza Virus-Induced Cell Death, and Pulmonary InflammationSemantic proximity Read ↗

Zinc-finger CCHC-type containing protein 8 promotes RNA virus replication by suppressing the type-I interferon responsesSemantic proximity Read ↗

The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNASemantic proximity Read ↗

HCMV exploits STING signaling and counteracts IFN and ISG induction to facilitate dendritic cell infectionSemantic proximity Read ↗

Viral Induction of the Zinc Finger Antiviral Protein Is IRF3-dependent but NF-κB-independentSemantic proximity Read ↗

The BTK-DDX41 axis of the STING pathway is activated during cytomegalovirus lytic infectionSemantic proximity Read ↗

IFN Regulatory Factor 3 in Health and DiseaseSemantic proximity Read ↗

Modulation of the cGAS-STING DNA sensing pathway by gammaherpesvirusesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.