Article

The zinc finger antiviral protein ZAP destabilises viral transcripts and restricts human cytomegalovirus

2020-09-17

Abstract excerpt

Interferon-stimulated gene products (ISGs) play a crucial role in early infection control. The ISG zinc finger CCCH-type antiviral protein 1 (ZAP/ZC3HAV1) antagonises several RNA viruses by binding to CG-rich RNA sequences, whereas its effect on DNA viruses is largely unknown. Here, we decipher the role of ZAP in the context of human cytomegalovirus (HCMV) infection, a β-herpesvirus that is associated with high mo...

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Identifiers and source

Literature Corpus work: abf0753a-8c88-5ec7-82e2-e8a82b54fb16
DOI: 10.1101/2020.09.15.297804

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