Article

The BTK-DDX41 axis of the STING pathway is activated during cytomegalovirus lytic infection

2024-10-03

Abstract excerpt

The innate immune response is the first line of defense against invading pathogens, including the betaherpesvirus, human cytomegalovirus (CMV). The host’s innate response acts as the first line of defense, and CMV, like other viruses, has consequently evolved multiple mechanisms to manipulate host interferon (IFN) responses. DEAD-box Helicase 41 (DDX41) is an intracellular dsDNA sensor that, upon activation by Bru...

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Literature Corpus work: db17b142-23e8-5c5e-bede-3093995b6fe4
DOI: 10.1101/2024.10.03.616496

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