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Article

Viral Induction of the Zinc Finger Antiviral Protein Is IRF3-dependent but NF-κB-independent

5 Jan 2010

Abstract excerpt

The zinc finger antiviral protein (ZAP) is an interferon-stimulated gene that restricts the replication of retroviruses, alphaviruses, and filoviruses. Relatively little is known, however, regarding the detailed mechanism of ZAP induction during viral infections. We show that, although being inducible by either interferon or virus, expression of ZAP is more efficiently activated by virus than are several other...

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PMID: 20048147
DOI: 10.1074/jbc.m109.054486

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