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Article

ZBP1: A Powerful Innate Immune Sensor and Double-Edged Sword in Host Immunity

6 Sept 2022

Abstract excerpt

Z-conformation nucleic acid binding protein 1 (ZBP1), a powerful innate immune sensor, has been identified as the important signaling initiation factor in innate immune response and the multiple inflammatory cell death known as PANoptosis. The initiation of ZBP1 signaling requires recognition of left-handed double-helix Z-nucleic acid (includes Z-DNA and Z-RNA) and subsequent signaling transduction depends on the...

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PMID: 36142136
DOI: 10.3390/ijms231810224

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