Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MODY7 Gene, KLF11, Is a Novel p300-dependent Regulator of Pdx-1 (MODY4) Transcription in Pancreatic Islet β Cells

21 Oct 2009

Abstract excerpt

Pdx-1 (pancreatic-duodenal homeobox-1), a MODY4 homeodomain transcription factor, serves as a master regulator in the pancreas because of its importance during organogenesis and in adult islet insulin-producing beta cell activity. Here, we show that KLF11, an SP/Krüppel-like (SP/KLF) transcription factor, mutated in French maturity onset diabetes of the young patients (MODY7), regulates Pdx-1 transcription in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Genetic Syndromes and Imprinting
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19843526
DOI: 10.1074/jbc.m109.028852

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MODY7 Gene, KLF11, Is a Novel p300-dependent Regulator of Pdx-1 (MODY4) Transcription in Pancreatic Islet β CellsPMID 19843526Read ↗

Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300.Semantic proximity Read ↗

A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young.Semantic proximity Read ↗

First Japanese Family With PDX1-MODY (MODY4): A Novel PDX1 Frameshift Mutation, Clinical Characteristics, and ImplicationsSemantic proximity Read ↗

A novel KLF11 variant in a family with maturity-onset diabetes of the young.Semantic proximity Read ↗

Genome-wide analysis of PDX1 target genes in human pancreatic progenitors.Semantic proximity Read ↗

Research Resource: The Pdx1 Cistrome of Pancreatic IsletsSemantic proximity Read ↗

Allele-specific transcriptional activity at type 2 diabetes-associated single nucleotide polymorphisms in regions of pancreatic islet open chromatin at the JAZF1 locus.Semantic proximity Read ↗

Identification of PCIF1, a POZ Domain Protein That Inhibits PDX-1 (MODY4) Transcriptional ActivitySemantic proximity Read ↗

HNF-4alpha: from MODY to late-onset type 2 diabetes.Semantic proximity Read ↗

Derivation and molecular characterization of pancreatic differentiated MODY1-iPSCsSemantic proximity Read ↗

Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)Semantic proximity Read ↗

PDX1 directs a core developmentally and evolutionarily conserved gene program in the pancreatic isletSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.