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Article

HNF-4alpha: from MODY to late-onset type 2 diabetes.

Trends in molecular medicine - 1 Nov 2004

Gupta Rana K, Kaestner Klaus H

Abstract excerpt

Maturity-onset diabetes of the young (MODY) is a rare subtype of type 2 diabetes that is characterized by autosomal-dominant inheritance and can be caused by mutations in hepatocyte nuclear factor 4alpha (HNF-4alpha). Odom and colleagues have combined chromatin immunoprecipitation with promoter m...

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Identifiers

PMID: 15519277
DOI: 10.1016/j.molmed.2004.09.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15519277-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

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HNF-4alpha: from MODY to late-onset type 2 diabetes.PMID 15519277Read ↗

Molecular etiologies of MODY and other early-onset forms of diabetes.Semantic proximity Read ↗

Molecular mechanism of HNF-1A–mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetesSemantic proximity Read ↗

A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young.Semantic proximity Read ↗

The role of transcription factors in maturity-onset diabetes of the young.Semantic proximity Read ↗

Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)Semantic proximity Read ↗

Regulation of pancreatic beta-cell function by the HNF transcription network: lessons from maturity-onset diabetes of the young (MODY).Semantic proximity Read ↗

Control of Pancreas and Liver Gene Expression by HNF Transcription FactorsSemantic proximity Read ↗

The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism.Semantic proximity Read ↗

[Mutations in the genes of the HNF-family cause maturity-onset diabetes of the young (MODY)].Semantic proximity Read ↗

Mutations in the genes encoding the transcription factors hepatocyte nuclear factor 1 alpha and 4 alpha in maturity-onset diabetes of the young and hyperinsulinemic hypoglycemia.Semantic proximity Read ↗

Roles of HNF1α and HNF4α in pancreatic β-cells: lessons from a monogenic form of diabetes (MODY).Semantic proximity Read ↗

Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function.Semantic proximity Read ↗

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