Article
Genome-wide analysis of PDX1 target genes in human pancreatic progenitors.
Molecular metabolism - 1 Mar 2018
Wang Xianming, Sterr Michael, Burtscher Ingo, Chen Shen, Hieronimus Anja, Machicao Fausto, Staiger Harald, Häring Hans-Ulrich, Lederer Gabriele, Meitinger Thomas, Cernilogar Filippo M, Schotta Gunnar, Irmler Martin, Beckers Johannes, Hrabě de Angelis Martin, Ray Michael, Wright Christopher V E, Bakhti Mostafa, Lickert Heiko
Abstract excerpt
OBJECTIVE: Homozygous loss-of-function mutations in the gene coding for the homeobox transcription factor (TF) PDX1 leads to pancreatic agenesis, whereas heterozygous mutations can cause Maturity-Onset Diabetes of the Young 4 (MODY4). Although the function of Pdx1 is well studied in pre-clinical models during insulin-producing β-cell development and homeostasis, it remains elusive how this TF controls human...
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