Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of PCIF1, a POZ Domain Protein That Inhibits PDX-1 (MODY4) Transcriptional Activity

30 Apr 2004

Abstract excerpt

Hox factors are evolutionarily conserved homeodomain-containing transcription factors that activate and repress gene expression in a precise temporally and spatially regulated manner during development and differentiation. Pancreatic-duodenal homeobox 1 (PDX-1) is a Hox-type protein that is a critical requirement for normal pancreas development and for proper differentiation of the endocrine pancreas. In humans,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes and associated disorders
Share to Diabetes Management and Research
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15121856
DOI: 10.1128/mcb.24.10.4372-4383.2004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of PCIF1, a POZ Domain Protein That Inhibits PDX-1 (MODY4) Transcriptional ActivityPMID 15121856Read ↗

Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in miceSemantic proximity Read ↗

Two conserved domains in PCIF1 mediate interaction with pancreatic transcription factor PDX-1.Semantic proximity Read ↗

Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus.Semantic proximity Read ↗

MODY7 Gene, KLF11, Is a Novel p300-dependent Regulator of Pdx-1 (MODY4) Transcription in Pancreatic Islet β CellsSemantic proximity Read ↗

Pancreatic duodenal homeobox factor-1and diabetes mellitus type 2 (Review)Semantic proximity Read ↗

Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development.Semantic proximity Read ↗

PDX1 directs a core developmentally and evolutionarily conserved gene program in the pancreatic isletSemantic proximity Read ↗

Transcription Factors in Islet Development and Physiology: Role of PDX‐1 in Beta‐Cell FunctionSemantic proximity Read ↗

Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300.Semantic proximity Read ↗

PDX1 Binds and Represses Hepatic Genes to Ensure Robust Pancreatic Commitment in Differentiating Human Embryonic Stem CellsSemantic proximity Read ↗

The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in miceSemantic proximity Read ↗

Genome-wide analysis of PDX1 target genes in human pancreatic progenitors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.