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Article

Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300.

Endocrinology - 1 Jun 2004

Stanojevic Violeta, Habener Joel F, Thomas Melissa K

Abstract excerpt

The homeodomain transcription factor, pancreas duodenum homeobox (PDX)-1, is essential for pancreas development, insulin production, and glucose homeostasis. Mutations in pdx-1(ipf-1) are associated both with maturity-onset diabetes of the young and type 2 diabetes. PDX-1 interacts with multiple transcription factors and coregulators, including the coactivator p300, to activate the transcription of the insulin...

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Identifiers

PMID: 15001545
DOI: 10.1210/en.2003-1188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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