Article

PDX1 directs a core developmentally and evolutionarily conserved gene program in the pancreatic islet

2021-02-28

Abstract excerpt

<h4>Summary</h4> Pancreatic and duodenal homeobox 1 (PDX1) is crucial for pancreas organogenesis, yet the dynamic changes in PDX1 targets in mouse or human pancreas development have not been examined. We integrated the PDX1 cistrome with cell lineage-specific gene expression in both mouse and human developing pancreas. We identified a core set of developmentally and evolutionarily conserved PDX1 bound genes that...

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Literature Corpus work: 4f6a41fa-6853-55c3-b5f9-01b7d006f522
DOI: 10.1101/2021.02.28.433241

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