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Article

Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)

Nature - 5 Dec 1996

Yamagata K, Furuta H, Oda N, Kaisaki P J, Menzel S, Cox N J, Fajans S S, Signorini S, Stoffel M, Bell G I

Abstract excerpt

The disease maturity-onset diabetes of the young (MODY) is a genetically heterogeneous monogenic form of non-insulin-dependent (type 2) diabetes mellitus (NIDDM), characterized by early onset, usually before 25 years of age and often in adolescence or childhood, and by autosomal dominant inherita...

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Diabetes Mellitus, Type 2
DNA-Binding Proteins
Exons
Gene Expression Regulation
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nuclear Proteins

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PMID: 8945471
DOI: 10.1038/384458a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-8945471-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)PMID 8945471Read ↗

Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)Semantic proximity Read ↗

Identification of nine novel mutations in the hepatocyte nuclear factor 1 alpha gene associated with maturity-onset diabetes of the young (MODY3).Semantic proximity Read ↗

Hepatocyte nuclear factor 1 alpha (HNF-1 alpha) mutations in maturity-onset diabetes of the young.Semantic proximity Read ↗

Molecular etiologies of MODY and other early-onset forms of diabetes.Semantic proximity Read ↗

Mutations in the genes encoding the transcription factors hepatocyte nuclear factor 1 alpha (HNF1A) and 4 alpha (HNF4A) in maturity-onset diabetes of the young.Semantic proximity Read ↗

Mutations in the genes encoding the transcription factors hepatocyte nuclear factor 1 alpha and 4 alpha in maturity-onset diabetes of the young and hyperinsulinemic hypoglycemia.Semantic proximity Read ↗

Molecular and biochemical analysis of the MODY syndromesSemantic proximity Read ↗

Maturity-Onset Diabetes of the Young (MODY): Genetic and Clinical CharacteristicsSemantic proximity Read ↗

The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism.Semantic proximity Read ↗

Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences.Semantic proximity Read ↗

Maturity-onset diabetes of the young: from clinical description to molecular genetic characterization.Semantic proximity Read ↗

[Mutations in the genes of the HNF-family cause maturity-onset diabetes of the young (MODY)].Semantic proximity Read ↗

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