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A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young.

Human molecular genetics - 15 Sept 2001

Thomas H, Jaschkowitz K, Bulman M, Frayling T M, Mitchell S M, Roosen S, Lingott-Frieg A, Tack C J, Ellard S, Ryffel G U, Hattersley A T

Abstract excerpt

Maturity-onset diabetes of the young (MODY) is a monogenic, autosomal dominant subtype of early-onset diabetes mellitus due to defective insulin secretion by the pancreatic beta-cell in humans. Five different genes have been identified including those encoding the tissue-specific transcription factors expressed in pancreatic beta-cells, i.e. HNF-4alpha (MODY1), HNF-1alpha (MODY3), IPF-1 (also known as PDX-1,...

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PMID: 11590126
DOI: 10.1093/hmg/10.19.2089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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